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Radiological Chemistry
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Dr Robert H Mach.
Robert H Mach, PhD
Division Head
Office: 4402C Clinical Sciences Research Building
Tel: 314.362.8538
Fax: 314.362.9940
machr@wustl.edu
 
Washington University School of Medicine
Div of Radiological Sciences
Campus Box 8225
510 South Kingshighway
St. Louis, MO 63110-1016

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Education
PhD, Medicinal Chemistry, State University of New York at Buffalo 1985
BA, Chemistry, State University of New York-College at Potsdam 1978

Professional History
Director 2007 - present
Division of Radiological Sciences,
Mallinckrodt Institute of Radiology,
Washington University School of Medicine, St. Louis, MO

Professor 2002 - present
Division of Radiological Sciences,
Mallinckrodt Institute of Radiology,
Washington University School of Medicine, St. Louis, MO

Vice Chairman for Research 2000 - 2002
Department of Radiology,
Wake Forest University School of Medicine, Winston-Salem, NC

Professor 2000 - 2002
Departments of Radiology/Physiology & Pharmacology,
Wake Forest University School of Medicine, Winston-Salem, NC

Associate Professor 1995 - 2000
Departments of Radiology/Physiology & Pharmacology,
Wake Forest University School of Medicine, Winston-Salem, NC

Assistant Professor 1992 - 1995
Departments of Radiology/Physiology & Pharmacology,
Wake Forest University School of Medicine, Winston-Salem, NC

Research Assistant Professor 1988 - 1992
Department of Neurology,
University of Pennsylvania

Research Assistant Professor 1987 - 1992
Department of Radiology,
University of Pennsylvania

Research Assistant Professor 1986 - 1987
Department of Nuclear Medicine,
SUNY at Buffalo, NY

Research Instructor 1985 - 1986
Department of Nuclear Medicine,
SUNY at Buffalo, NY

NIH Predoctoral Fellow 1983 - 1985
Department of Medicinal Chemistry,
SUNY at Buffalo, NY

Professional Societies
American Chemical Society
Society of Nuclear Medicine
New York Academy of Sciences
Society for Neuroscience

Selected Publications
  1. Hammond PS, Cheney JT, Johnston DE, Ehrenkaufer RL, Luedtke RR and Mach RH. Synthesis, in vitro dopamine D2 and D3 receptor binding and quantitative structure-activity studies on substituted 2,3-dimethoxy-N-1-benzyl-4-piperidinyl)benzamides and related compounds. Med Chem Res 1999; 9: 35-49.

  2. Gage HD, Gage JC, Chiari A., Xu Z.-M., Mach RH, Efange SMN, Ehrenkaufer RLE and Esienach JC. In vivo imaging of spinal cord cholinergic system with positron emission tomography. Journal of Computer Assisted Tomography 1999; 23:25-33.

  3. Efange SMN, Khare AB, Mach RH, Parsons SM. Hydroxylated decahydroquinolines as ligands for the vesamicol acetylcholine transporter: synthesis and biological evaluation. J Med Chem 1999; 42: 2862-2869.

  4. Nader M.A., Grant KA, Gage HD, Ehrenkaufer RL, Kaplan JR and Mach RH. PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia. Neuropsychopharmacology 1999; 21: 589-596.

  5. Al-Nabulsi I, Mach RH, Sten K, Childers SR and Wheeler KT. Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumor cells. British Journal of Cancer 1999; 81: 925-933.

  6. Nader MA, Green KL, Luedtke RR and Mach RH. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology 1999; 147: 143-152.

  7. Mach RH, Hammond PS, Huang Y, Yang B, Xu Y, Cheney JT, Freeman R and Luedtke RR. Structure-activity relationship studies of N-(9-benzyl)-9-azabicyclo[3.3.1]nonan-3�yl benzamide analogues for dopamine D2 and D3 receptors. Medicinal Chemistry Research 1999; 9:355-373.

  8. Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM and Davies HML. Fluorine-18 labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse 2000; 37:109-117.

  9. Wheeler KT, Wang L-M, Wallen CA, Childers SR, Cline JM, Keng PC and Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumors. British Journal of Cancer 2000; 82:1223-1232.

  10. Gage HD, Voytko ML, Ehrenkaufer RLE, Tobin JR, Efange SMN and Mach RH. Reproducibility of [18F](+)-4-fluorobenzyltrozamicol and positron emission tomography in the rhesus monkey brain. J Nucl Med 2000; 41: 2069-2076.

  11. Luedtke RR, Freeman RA, Boundy V, Martin MW, Huang Y, Mach RH. Characterization of 125I-IABN, a novel benzamide selective for D2-like dopamine receptors. Synapse 2000; 38:438-449.

  12. Efange SMN, Tu Z, von Holberg K, Khare AB, Tu Z, Mach RH, Parsons SM. Synthesis and biological characterization of stable and radioiodinated (+)-trans-2-hydroxy-3-[4-(3-iodophenyl)piperidinyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM). Nucl Med Biol 2000; 27:749-755.

  13. Voytko ML, Mach RH, Gage HD, Ehrenkaufer RLE, Efange SMN, Tobin JR. Cholinergic activity of aged rhesus monkeys revealed by PET. Synapse 2001; 39:95-100.

  14. Gage HD, Gage JC, Tobin JR, Chiari A, Xu Z-M, Mach RH, Efange SMN, Ehrenkaufer RLE, Eisenach JC. Morphine-indiced spinal cholinergic activation: in vivo imaging with PET. Pain 2001; 91:139-145.

  15. Mach RH, Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Wang L-M, Ehrenkaufer RL, Wallen CA, Wheeler KT. [18F]N-4'-Fluorobenzyl-4-(3-bromophenyl)acetamide for imaging the sigma receptor status of tumors: comparison with [18F]FDG and [125I]IUDR. Nucl Med Biol 2001; 28:451-458.

  16. Mach RH, Yang B, Wu L, Kuhner RJ, Whirrett BR, West T. Synthesis and sigma receptor binding affinities of 8-azabicyclo[3.2.1]octan-3a-yl and 9-azabicyclo[3.3.1]nonan-3a-yl phenyl carbamates. Med Chem Res 2001; 10: 339-355.

  17. Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis of 2-(2,3,-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D2 and D3 receptors. Bioorgan Med Chem 2001; 9:3113-3122.

  18. Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. J Med Chem 2001; 44:1815-1826.

  19. Huang Y, Hammond P, Wu L, Mach RH. Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent s1 receptor ligands. J Med Chem 44 2001; 4404-4415.

  20. Mach RH, Wheeler KT, Blair S, Yang B, Day C, Choi SR, Kung KF. Preparation of a Technetium-99m SPECT Agent for imaging the sigma-2 receptor status of solid tumors. J Labelled Cmpds. Radiopharm 2001;44: 899-908.

  21. Choi S-R, Yang B, Plossl K, Chumpradit S, Wey S-P, Acton PD, Wheeler KT, Mach RH, Kung HF. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent. Nucl Med Biol 2001; 28: 657-666.

  22. Morgan D., Grant KA, Mach RH, Gage HD, Kaplan JR, Prioleau OA, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience 2002; 5: 169-174.

  23. Nader M.A., Sinnott R.S., Mach R.H., Morgan D. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist. Psychopharmacology 2002; 163: 292-301.

  24. Mach RH, Huang Y-H, Freeman RA, Wu L, Blair S, Luedtke RR. Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors. Bioorganic and Medicinal Chemistry 2003; 11: 225-233.

  25. Luedtke R.R. and Mach R.H. Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychological disorders. Current Pharmaceutical Design 2003, 9: 643-671.

  26. Mach RH, Vangveravong S, Huang Y, Yang B, Blair JB, Wu L. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3a-yl phenylcarbamate analogs as sigma-2 receptor ligands. Medicinal Chemistry Research 2003, 11: 380-398.

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